Изменение факторов иммунного ответа при терапии цервикальных интраэпителиальных неоплазий

Abstract

Th e aim of the research. Assessment of changes in immune response factors during antiviral therapy of cervical intraepithelial neoplasia of severity grades I and II against the background of human papillomavirus. Material and methods. An outpatient examination of 232 female subjects of reproductive age was carried out. Among these, 172 women were with a histologically confi rmed diagnosis of mild to moderate cervical intraepithelial neoplasia (CIN I-II) associated with papillomavirus infection. During the work, each patient underwent cytological and colposcopic examination as well as real-time HPV typing with viral load evaluation. To establish the fi nal diagnosis, if necessary, a multifocal biopsy of the cervix was used. Within the framework of the designated goal, changes in the cervical zone were studied and analysed by means of assessing caspase-3, caspase-9, IFN-γ, IL-18. Results. As part of the study, changes in the caspase and cytokine profi le were analysed in HPV-associated cervical intraepithelial neoplasia of grades I-II, which substantiated the use of immune system correction for successful treatment of patients with mild to moderate dysplastic processes. Conclusion. The results obtained in the study make it possible to optimise management of patients with HPV-associated cervical intraepithelial neoplasia of severity degrees I-II.