Abstract
The objective of the present study was to investigate the effects of a high-fat diet and swimming exercise on neuropeptide hormone orexin and browning of white adipose tissue. Accordingly, a high-fat diet was administered and a swimming exercise regimen was applied for 6 weeks to 32 male Sprague-Dawley rats. In the comparison between the groups, body fat mass was significantly lower. The amount of dietary intake was significantly higher in the highfat diet group. Although there were no significant changes in orexin hormone levels in blood. With respect to heat generating factors, the high-fat diet + exercise and high-fat diet group showed significantly higher expression of PGC-1α and UCP-1 in muscles. The high-fat diet and high-fat diet + exercise groups showed a significantly higher expression of FNDC5 in fat tissues, whereas the high-fat diet group showed significantly higher expression of UCP-1 in fat tissues. The findings of the present study revealed that regular exercise stimulates the hypothalamus of the brain to regulate the function of orexin, a neuropeptide hormone, which promotes the expression of heat generating factors PGC-1α, FNDC5, and UCP-1, However, the future studies might have a positive impact on obesity treatment and improvement.
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