화학적 발암원을 투여한 마우스 모델에서 규칙적인 유산소운동의 대장암 형성 억제효과

Abstract

We investigated the effect of regular aerobic exercise on colon tumorigenesis associated with inflammatory factors, such as interleukin-1β(IL-1β), interleukin-6 (IL-6), monocyte chemoatractant protein-1 (MCP-1) and tumor necrosis factor-α(TNF-α), in azoxymethan/dextran sulfate sodium (AOM/DSS) -administrated mice. ICR mice (5 weeks o ld) were divided into three g roups of 10 animals each, consisting of a control group (CON), an AOM/DSS treatment group (AOM/DSS), and an AOM/DSS treatment plus exercise group (AOM/DSS+Ex). The AOM/DSS+Ex group performed five times per week, for a total of 45 minutes, at a speed of 20 m per minute, using a treadmill with a gradient of 5% for 12 weeks. To investigate the effects of regular aerobic exercises on inflammation and formation of colorectal cancer, we carried out colorectal histopathologic analysis, colon tumor number counting and tumor-related inflammatory cytokine analysis. The number of colon tumors in the AOM/DSS+Ex group was approximately 25% lower than in the AOM/DSS group, but no statistically significant. In colon weight and length, there was no significantly difference between AOM/DSS group and AOM/DSS+Ex group. On the other hand, there were significant reductions in tumor-related inflammatory cytokines, IL-6 and TNF-α(P＜.05) between AOM/DSS group and AOM/DSS+Ex group, but not in IL-1β and MCP-1. In conclusion, this exercise protocol resulted in partial anti-inflammatory and -tumor effects. Therefore, it is necessary to carry out further studies by diverse exercise protocols to establish colon cancer prevention program.