Abstract
Optical and electron microscopy, quantitative cytochemistry and morphometric analysis were used to look into structural and functional transformations in the bloodstream, adrenal cortex corticosterocytes and adrenal brain cells in consequence of exposure to modeled acute and chronic gravitational stresses (AGS and CGS respectively). AGS caused adrenal hyperemia, hypertrophy of the zona fasciculata, elevated activity of enzymes involved in mitochondrial and extramitochondrial oxidation, and secretion of undissolved catecholamine granules in the capillary bloodstream. CGS depressed mitochondrial oxidation, activated glycolysis, produced destructive changes in corticosteroids, and LED lipid droplets in capillary lumen. From capillaries the fat droplets traveled further to the brain sinusoids where they deposited together with blood corpuscles (erythrocytes primarily) and formed microcirculation impairing microemboli. Thereupon we assume that the source of lipid droplets under the full-strength gravitational stress is intermediate products of corticoid synthesis in conditions of mitochondria destruction and disturbed mitochondrial metabolism in cells of the fasciculata and glomerulosa zones.
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