Біохімічні показники ротової рідини у наркозалежних хворих на хронічний генералізований пародонтит

Abstract

The impact of narcotic drugs on the oral cavity is not sufficiently studied and remains important. The aim of the study – to learn the biochemical characteristics of oral liquid of drug-addict patients with chronic generalized periodontitis of initial and first degree. Materials and Methods. The object of biochemical studies was oral liquid of 14 drug addict patients (main group) and 10 non-drug addict patients (comparison group) with chronic generalized periodontitis initial and first degree (CGP). There were determined the following parameters: salivation rate, pH, catalase activity (method described by Koroliuk et al.), the number of MDA (by – Stalnaia et al.) and counted API index, protein (by – Lowry), acid and alkaline phosphatase (sets to determine enzymatic activity produced by "Filist-diagnostics"), proteases activity (Kunitz in modification of A.P. Levytskyi).Results and Discussion. We found out deviation of pH in the acidic side (6.16 ± 0.12) in addicted patients and reduce in the rate of salivation (0.31 ± 0.02 ml/m); Also there was reduced in catalase activity (0.14 ± 0.02 mcat/l) and increase in the number of MDA (0.31 ± 0.02 mmol/l) in patients of the main group and API index decrease in addicted patients to 4.47±0.64. Rising of results of protease activity in 7.1 %, protein – in 14.3 %, and acid phosphatase to 25.04±0.72U/l in patients of the main group. Activity of alkaline phosphatase was reduced to 42.55 ± 0.82 U/l. Conclusion. Biochemical studies of oral liquid drug dependent patients with CGP confirm the weakening protective mechanisms and progression of pathological process in periodontal tissues.