Abstract
Drusenoid pigment epithelial detachment is a condition characterized by separation of the retinal pigment epithelium from the underlying Bruch’s membrane due to formation of drusenoid deposits. The disorder represents the intermediate stage of the age-related macular degeneration, and is a risk factor for the age-related macular degeneration progression to late stage characterized by geographic atrophy, which results in the irreversible central vision loss. Management of patients with this disorder is in most cases limited to follow-up. The feasibility of using the multimodality low power mode laser therapy for treatment of drusenoid pigment epithelial detachment is reported. The results of laser photocoagulation of the retina demonstrate the morphological and functional recovery: retinal pigment epithelial detachment sealing, improvement of visual function, and restored retinal architecture.
Highlights
Age-related macular degeneration (AMD) is among the leading causes of the irreversible central vision loss, occurring predominantly in the elderly
In accordance with the generally accepted classification of the Age-Related Eye Disease Study (AREDS), age-related macular degeneration (AMD) is subdivided into four categories
It is believed that this disorder results from the gradual increase and merging of the large number of pre-existing soft drusen, which results in the focal retinal detachment of at least 350 μm in diameter
Summary
The AREDS Category 3 (intermediate stage AMD) is characterized by numerous medium-sized drusen, and/or one large druse of more than 125 μm in diameter, or RPE atrophy, not affecting the retinal center. Drusenoid pigment epithelial detachment (DPED), in which RPE and its basement membrane are separated from the inner collagen layer of the underlying Bruch’s membrane due to formation and accumulation of drusenoid material, represents the intermediate stage of AMD. This form of PED was originally described by A. With increasing DPED, the prolonged dissociation between the RPE cells and the Bruch's membrane/choriocapillaris complex leads on the one hand to the RPE cells' migration into the outer retinal layer, BULLETIN OF RSMU | 6, 2021 | VESTNIKRGMU.RU
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