고지방식이 섭취시 그라비올라 음용과 수영 운동이 지방대사 및 장내미생물에 미치는 영향

Abstract

This study aimed to investigate the effects of graviola Ingestion and swimming exercise on lipid metabolism and gut microbiome during the consumption of a high-fat diet. Forty-two male Sprague-Dawley rats were fed a high-fat diet and graviola Ingestion and were subjected to swimming exercise for 6 weeks. In terms of the food intake amount and dietary efficiency, a significant decrease in food intake amount and a significant increase in dietary efficiency was observed in the high-fat diet group. Analysis of lipid metabolism showed that PPAR-α expression was significantly high in the normal diet and the swimming groups and AMPK expression was significantly high in the swimming, the high-fat diet+swimming, and the high-fat diet+graviola Ingestion groups. Furthermore, L-FABP expression in liver tissues was significantly high in the swimming and the high-fat diet+exercise group, and CPT-1 expression was significantly high in the normal diet group. With regard to fecal Bacteroidetes and Firmicutes, a significant increase was seen in the abundance of Bacteroidetes in the normal diet, the high-fat diet+graviola Ingestion, and the high-fat diet+graviola Ingestion group+swimming groups, and a significant increase in the abundance of Firmicutes was seen in the normal diet, the high-fat diet+graviola Ingestion, and the high-fat diet+graviola Ingestion+swimming groups. Together, the findings of this study concerning regular exercise and graviola Ingestion indicate the effects of various medicinal ingredients contained in graviola. Furthermore, this study demonstrates positive results on graviola functionality; although mechanism underlying this graviola functionality has not been elucidated, this study and its findings are expected to have a positive influence in laying the groundwork for future studies on biologically active substances present in graviola and its application as a functional food.