МОДЕЛЬ РАЗВИТИЯ БИСФОСФОНАТ-АССОЦИИРОВАННОГО ОСТЕОМИЕЛИТА НИЖНЕЙ ЧЕЛЮСТИ В ЭКСПЕРИМЕНТЕ С ЛАБОРАТОРНЫМИ КРЫСАМИ

Abstract

Purulent-inflammatory diseases of the maxillary system remain one of the urgent problems in the work of dentists and maxillofacial surgeons due to the high frequency, increased severity and prevalence of the process, a tendency to relapse, and increased antibiotic resistance due to a long period of uncontrolled use of the latter by the population. The choice of the bisphosphonate-associated osteomyelitis model is due, on the one hand, to the widespread use of this group in a number of malignant neoplasms, osteoporosis, and, on the other, to the frequent development of osteonecrosis of the jaw as a complication of bisphosphonate therapy, which can occur after any surgical dental procedure. The undoubted advantage of this model is the relative simplicity of its execution technique, which does not require an expensive material and technical base, the use of highly pathogenic and highly contagious microorganisms, keeping animals in a bacteriological laboratory, and the safety of conducting experiments. Experimental modeling of bisphosphonate-associated osteomyelitis may reveal new aspects in the etiopathogenesis of diseases of the maxillofacial region and justify the correction of nondrug and pharmacotherapeutic approaches to the prevention and treatment of complications.