Abstract
Currently, there is no cure for pediatric diffuse brain stem (BS) tumors. Radiotherapy, including proton therapy, is an important component of combination treatment for this cancer, especially in children with a complicated medical history. The article addresses the issues of therapy for pediatric BS tumors and reports the use of proton re-irradiation in a 9-year-old boy with unverified diffuse BS tumor. Proton re-irradiation is an effective treatment option that can sustain and improve the quality of life and prolong survival in children with diffuse BS tumors.
Highlights
CLINICAL CASE ONCOLOGYUdalov YuD1, Slobina EL1 , Danilova LA1, Zheludkova OG2, Kiselev VA1,4, Nezvetsky AV1, Demidova AM1,4, Ivanov AV1, Dykina AV3
Optimized intensity-modulated proton therapy [17] for the metabolically active recurrent lesion was delivered to the patient at the Federal Research and Clinical Center for Medical Radiology and Oncology from January 26, 2021 to March 5, 2021
As more evidence is being accumulated about the safety of this approach for treating pediatric CNS tumors, re-irradiation is being increasingly used to manage recurrent/progressive Diffuse intrinsic pontine glioma (DIPG) in children [28,29,30]
Summary
Udalov YuD1, Slobina EL1 , Danilova LA1, Zheludkova OG2, Kiselev VA1,4, Nezvetsky AV1, Demidova AM1,4, Ivanov AV1, Dykina AV3. Proton re-irradiation is an effective treatment option that can sustain and improve the quality of life and prolong survival in children with diffuse BS tumors. ВОЗМОЖНОСТИ ПРОТОННОЙ ТЕРАПИИ ПРИ ПОВТОРНОМ ОБЛУЧЕНИИ ДИФФУЗНОЙ ОПУХОЛИ СТВОЛА МОЗГА У ДЕТЕЙ. В статье обсуждены вопросы специального противоопухолевого лечения диффузных опухолей ствола мозга у детей и представлен сложный клинический случай повторной лучевой терапии рецидива неверифицированной диффузной опухоли СМ у девятилетнего мальчика с применением протонной терапии (ПТ). В. Незвецкий — проведение противоопухолевого лечения с применением протонной терапии; А. Therapy against childhood BS tumors seeks to sustain or improve the quality of life and prolong survival. This goal can be achieved through using state-of-the-art RT, including proton RT [17, 18]
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