Abstract
Bronchial asthma is a chronic inflammatory disease of the respiratory tract characterized by reversible bronchial obstruction and bronchial hyperreactivity. The neutrophilic endotype of bronchial asthma is associated with an aggressive course of the disease, severe tissue destruction and a low response to standard corticosteroid therapy. All of the above indicates the need to create new drugs for the treatment of neutrophilic asthma, which requires adequate animal models of this disease. We have proposed a protocol for the induction of experimental neutrophilic bronchial asthma in mice, which includes intraperitoneal immunization with a mixture of a model allergen of ovalbumin and Freund's adjuvant followed by aerosol challenge with the same allergen mixed with the lipopolysaccharide. This approach made it possible to reproduce the main manifestations of neutrophilic bronchial asthma: the production of IgE allergen-specific antibodies, the development of bronchial hyperreactivity, respiratory tract remodeling and the lung tissue infiltration with neutrophils. bronchial asthma, murine model, neutrophils The work was supported by the Grant of the President of the Russian Federation (no. MD-1578.2019.4).
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