ЗАБОЛЕВАЕМОСТЬ И СМЕРТНОСТЬ ОТ ОПУХОЛЕЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ В КОГОРТЕ РАБОТНИКОВ, ПОДВЕРГШИХСЯ ХРОНИЧЕСКОМУ ОБЛУЧЕНИЮ

Abstract

Purpose: To analyze incidence and mortality rates of central nervous system (CNS) primary tumors (PT) in the cohort of workers chronically exposed to radiation. Material and methods: Study cohort included 22237 Mayak Production Association workers. Work history data and dose estimates from the “Mayak Worker Dosimetry System 2013” were used. Clinical and epidemiology data were obtained from the “Clinic” database. Crude and age-adjusted (by indirect method) incidence and mortality rates for CNS PT per 100000 person-years were calculated. Standardized incidence and mortality trends were analyzed by Jointpoint 4.0.4. Results: 53 cases and 47 deaths from malignant neoplasms (MN) of brain and spinal cord, cerebral nerve and other parts of CNS (C70–C72 ICD-10 codes) as well as 40 cases and 7 deaths from non-malignant neoplasms (NMN) of brain and other parts of CNS (D-33 ICD-10 code) were identified. CNS MN were more frequent among males (83 %), and CNS NMN were more frequent among females (55 %). Both CNS MN and NMN developed at younger ages among males as compared with females, CNS PT frequency increased with increased attained age. Analysis in relation to calendar period revealed the increasing trend for CNS PT incidence among females only (р=0,008). Effects of chronic occupational radiation exposure on CNS PT incidence and mortality rates were not established either among males or females. Conclusion: Findings should be considered as preliminary and require further studies.