ИЗМЕНЕНИЯ ГЕМАТОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ ПРИ ИСПОЛЬЗОВАНИИ ОСТЕОПЛАСТИЧЕСКОГО БИОКОМПОЗИЦИОННОГО МАТЕРИАЛА ДЛЯ ВОССТАНОВЛЕНИЯ КОСТНОЙ ТКАНИ У ЖИВОТНЫХ

Abstract

Damage, injuries and fractures of locomotor apparatus, agricultural, small unproductive, wild animals, are diagnosed in at least 30% of cases of the total number of non-infectious pathologies. In veterinary and humane medicine, complications associated with violation of the integrity of tubular bones have not been eliminated to date. Today, taking into account the various methods of osteosynthesis, where a variety of metal structures, spokes, pins, devices are used, it is definitely important to add biocomposites to the area of intramedullary space at the level of the fracture zone, to accelerate the consolidation process and prevent bacterial contamination. The article presents the hematological parameters of experimental animals (rabbits) using the developed biocompositional osteoplastic material injected into the intramedullary canal, with a simulated fracture followed by osteosynthesis. Samples of general and biochemical analysis of animal blood (n=60) served as the material for research. The purpose of this experiment and research was to evaluate hematological parameters using the developed biocomposite, with confirmation of the absence of undesirable complications of delayed and immediate type on the part of experimental animals. The authors determined, based on a clinical blood test, the absence of hematopoiesis inhibition and inflammatory reactions to a biocomposite consisting of sodium alginate, hydroxyappatite, distilled water, amoxicillin and methyluracil. Thanks to the study of biochemical blood analysis, the absence of intoxication activity of the biocomposite on the hepatobiliary and renal systems of experimental animals was determined. This osteoplastic biocomposite, from the point of view of a group of authors, accelerates the consolidation activity of bone fragments due to antibacterial, osteoconductive and osteoinductive effects.