Оособенности вызванной активности мозга при анализе изображений эмоциогенного характера у носителей полиморфных вариантов генов BDNF и HTR2A

Abstract

The article presents the results of the study of induced brain activity in carriers of polymorphic variants of the gene of the brain neurotrophic factor BDNF and the gene of the receptor serotonin HTR2A, obtained in the evaluation of stimulatory images of emotionogenic character. The image database used in the work included 573 images assigned to three groups: neutral, positive, negative. 40 people of both sexes aged 19—22 years were examined. The isolation of DNA from the buccal epithelium cells was carried out by PCR (OOO «BiReT», Moscow, Russia). During the genetic analysis, the following DNA sections were analyzed: Neurotrophic factor of the brain BDNF, Serotonin receptor HTR2A. To register the electroencephalogram and evoked potentials (EP) of the brain, a multichannel electroencephalograph Neurovisor-136 (manufactured by ISS, Russia) was used. The recording was carried out unipolarly according to the «5—5» scheme in 128 leads. As a result of the study, it was found that in persons with a heterozygous Val / Met genotype of the cerebral neurotrophic factor BDNF, a more pronounced emotional response to both positive and negative stimuli was observed. For persons with a homozygous Val / Val genotype, a more detailed treatment of the details of the visual image is characteristic. For persons with a dominant homozygous G / G genotype of the HTR2A serotonin receptor gene, weighted decision-making in stimulus analysis is characteristic. In individuals with recessive homozygous genotype A / A HTR2A, evaluating the visual stimulus as negative requires the use of significantly larger brain resources, compared to the carriers of the dominant allele G.