Определение изменений устойчивости молекулярного химического состава лекарственных препаратов, используемых при низкочастотной ультразвуковой терапии в оториноларингологии

Abstract

The article discusses the possibility and the results of applying the nuclear magnetic resonance spectroscopy (NMR spectroscopy) as an objective assessment of chemical stability of the molecular compositions of medical preparations used for phonophoretic injection into biological tissues by exposing them to low-frequency ultrasound. It is based on the interaction of an external magnetic field with the nuclei of the molecules of a substance, which, when exposed to a radio pulse of a certain frequency, change their energy levels, emitting electromagnetic radiation. This effect provides the image of the oscillations from all the resonating nuclei of chemical composition, state, and structure different from those of the analyte. The studied preparations are hydrocortisone suspension; dexamethasone solution; 2% lidocaine solution; lydasum aqueous solution; lydasum, dissolved in 2% lidocaine, before and after their single sonic treatment at the resonant frequency of 25–26 kHz for 120 seconds. The results of the study were evaluated by the spectral characteristics of samples of medicinal substances. It has been proven that these preparations after ultrasonic “agitation” preserve the identity of their molecular chemical composition and, within the designated period, can be used for phonophoretic injection into biological tissues. In general, the method of NMR spectroscopy should be recommended to check the integrity of any medicinal substances before their injection into human body using physical technologies. Keywords: medicinal solutions, low-frequency ultrasound, molecular chemical composition, nuclear magnetic resonance spectroscopy.