Abstract
The objective is to compare the effectiveness of complex bio-regulatory medication (CBRM) Viburcol, produced by «Biologishe Haylmittel Heel GmbH», Germany, with the reference product No-X-sha, produced by «Lekhim-Kharkov», which are used as antispasmodics, for preparation of uterine cervix for childbirth and prevention of labor anomalies. Patients and methods. 92 pregnant women aged 18 to 45 years, who were randomized into 2 groups: the main group (n=46) and the control (n=46) one, were involved in the study. Viburcol was used for the treatment of pathological preliminary period and prevention of development of labor anomalies. It was prescribed at the end of pregnancy and in the 1st stage of labor, in the morning and in the evening. Two Viburcol suppository every 3-4 hours were given at the onset of labor. Antispasmodic No-X-sha was used in the control group. It was studied the functional state of the sympathetic-adrenal system with fluorometric method, the concentration of noradrenaline (NA) and adrenaline (A) in the urine, to assess the neurohormonal regulation of labor. The plasma levels of b-estradiol and progesterone were determined to identify the risk of discoordination of labor activity and the state of uterine contractile function. Also, the parameters of uterine contractile activity were analyzed according to cardiotocography. Results. Usage of complex bio-regulatory medication Viburcol promotes adequate cervical ripening and incidence of discoordination of labor activity decreased by 1.5 times. CDRM Viburcol administration in childbirth facilitated the elimination of pathological levels of catecholamines, which led to the development of discoordination of labor activity. Conclusion. The results show the effectiveness of CDRM Viburcol (rectal suppositories) for the prevention of discoordination of labor activity. The medicine meets all modern requirements for antispasmodics and analgesics used during labor: it has analgesic, antispasmodic, anxiolytic effect, eliminates side reflex reactions, reduces the severity of birth stress, it has no adverse effect on the contractile activity of uterus and the fetus condition. Key words: complex bio-regulatory medications, bio-regulatory approach, labor amoralities, preparation of uterine cervix, Viburcol.
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