Оцінка небезпечності, комплексне гігієнічне нормування флорпірауксифен-бензилу та обґрунтування регламентів безпечного застосування гербіциду на його основі для захисту рису

Abstract

Florpyrauxifen-benzyl is a novel synthetic selective leaf herbicide of the pyridine group with an auxin mechanism of action. The drug Divixton EC (a.i. - florpyrauxifen-benzyl, 25 g/l) is suggestedfor protection of rice crops from weeds. For the state registration for agricultural use in Ukraine and to prevention of toxic impact on human health and quality of environment, risk assessment of the new plant protection product was conducted, and the safety criteria for human health and the environment were substantiated. The allowable daily dose of florpyrauxifen-benzyl for humans at the level of 0.02 mg/kg was substantiated; the hygienic standards for florpyrauxifen-benzyl in rice, working environment, air, water and soil, criteria for the control of the exposureon on workers, regulations for safe use of herbicide Divixton EC in agriculture have been developed. Objective. Toxicological and hygienic assessment of florpyrauxifen-benzyl and Divixton EC drug, substantiationof safety criteria for human health, assessment of the potential impact of florpyrauxifen-benzyl on agricultural workers and the population in case of ground and aerial spraying of the preparation for the protection of rice crops. Methods. Expert-analytical, toxicological, physical, chemical, statistical and hygienic. Results. Based on the parameters of acute toxicity for different routes of exposure, sensitizing properties and irritative effects on the mucous membranes of the eyes and the skin, florpyrauxifen-benzyl and herbicide Divixton EC are classified as moderately hazardous (category 3). Long-term effects (carcinogenicity, mutagenicity and teratogenicity, toxicity for the reproductive function and development) are not limiting criteria for the assessment of florpyrauxifen-benzyl hazard. Approved in Ukraine allowable of florpyrauxifen-ben-zyl for humans is 0.02 mg/kg. As a result of field tests conducted in Ukraine, it was found that the value of occupational risk due to inhalation and through the skin in the course of ground and aerial application of florpyrauxifen-benzyl did not exceed the accepted level, sanitary protection zones ensure the safety of herbicide application for the population and environmental objects; no residues of florpyrauxifen-benzyl were detected during the harvesting of in rice grain and rice paddy. Conclusion. Application of herbicide Divixton EC for rice protectionin accordance with agricultural and hygiene rules and regulations will not result in contamination of agricultural products and environmental objects and will be safe for population and agricultural workers. Key Words: herbicide, florpyrauxifen-benzyl, toxicological characteristics, hazard assessment, hygiene standards and regulations.